Our Physicians

E. Michael Holt, M.D.


Dr. Holt is a board certified orthopaedic surgeon who joined UOS in 1989 following his orthopaedic training at Campbell Clinic in Memphis. With over 29 years in orthopaedic surgery practice, Dr. Holt is one of the most experienced in the region. He has dedicated his practice to acute and chronic problems of the knee from traumatic injury to wear and tear across the lifespan. He has treated many athletes of varying ages and abilities, including those participating at the college and professional levels. Dr. Holt has a passion for helping all individuals lead active lifestyles, regardless of age, and he keeps up to date with the latest treatments and techniques.

With a special interest in knee replacements and having performed thousands, (over 500 annually), Dr. Holt offers 3 types: custom, standard, and robot-assisted or MAKO. In addition, he performs partial (unincorporated and patellofemoral) knee replacements. Dr. Holt provides experience, latest techniques and low complication rates to ensure the best possible outcomes for his patients. While performing the majority of surgeries at UT Medical Center, Dr. Holt also operates at Parkwest Medical Center and Tennova.

Dr. Holt holds a faculty position as clinical professor at the University of Tennessee Medical Center and mentors future physicians and other healthcare providers. He has been active in the community as an assistant Boy Scout leader and coach of youth soccer and basketball teams. He considers completion of his first marathon at age 55 to be a great achievement! Golf is a favorite hobby and beekeeping is a new passion.

On a personal note, Dr. Holt and Tresa, his wife of 34 years, enjoy outdoor activities, their 3 Weimaraner dogs, and spending time with their three grown children.  Andrew is a current orthopaedic surgery resident, Abigail is a Family Nurse Practitioner, and Ben is a recent graduate from ETSU where he was a scholarship Division 1 soccer player. He plans to do graduate studies in biology/ecology.

Dr. Holt's Educational Links

Contact Information

Office Info

U.T. Medical Center
Professional Office Building F
1926 Alcoa Highway Suite 210
Knoxville, TN 37920
Phone : 865.546.2663

West Knoxville
11440 Parkside Drive, Suite 110
Knoxville, TN 37934
Phone : 865.218.9300

Patient Testimonials


Thanks to my care at UOS, I can enjoy life again!

Dr. Holt replaced my left knee on February 6, 2018. I chose to have my physical therapy at the UOS Turkey Creek location because it is an easy drive from Maryville. Little did I know I'd hit the jackpot for physical therapy! Physical therapy is hard, but the encouraging atmosphere of this office made me actually look forward to going. I saw both John and Lea during my treatment. Each of them comforted me when I had concerns, challenged me to go beyond what I thought I could do, and encouraged me as I progressed. I also loved the camaraderie that developed between patients as we cheered each other's progress. The office never felt overcrowded, and I never felt rushed by my therapists. At 6 weeks, I have reached my goals and have been discharged from therapy. I was actually a little sad to leave. I will be scheduling my right knee replacement with Dr. Holt soon. There's nowhere else I'd go for this surgery or for my physical therapy afterwards!

Christy, - Total Knee Replacement

Thanks to my care at UOS, I can walk anywhere without pain in both knees.

I couldn't have scripted a better experience after having both knees replaced in a 6 month span. Dr. Michael Holt and his P.A., Erin Kramer were awesome!!! From my initial visit to my last visit yesterday, everything went as good as I could ever have imagined! Because of the great job they did, my post surgery P.T. was minimal. Other than what I call 'in the moment' pain, I have had very little pain! My post op visits were all great! I really couldn't have asked for more! I thank God publicly for them and the whole staff at UOS!

Bruce, - Total knee replacement of both knees

Thanks to my care at UOS, I had always thought I would go to the Cleveland Clinic for any major surgery. However, I am very happy Dr. Holt was recommended to me. The attention, care and dedication of Dr. Holt and his PA Erin Kramer was excellent, I could not have been in a better place. Like al good things I tell everyone I know who is considering knee replacement to look no further then UOS.

David, - Total Knee Replacement

Thanks to my care at UOS, I can do daily activities and function as a normal person.

Dr. Holt is very skilled at what he does and is a very caring doctor. I so appreciate the quality of like I have regained after having total knee replacement in both knees (about 4 months between surgeries). Dr. Holt, his PA, Erin Kramer, and his entire staff are wonderful. Thanks to you all for the wonderful treatment I received while under Dr. Holt's care.

Karen, - Total Knee Replacement

I would like to express my story about the Turkey Creek Therapy office. I have been so pleased and somewhat surprised about the high level of care the entire office demonstrates. Jody, at the front desk is efficient and caring. Lynne, my therapist does her job by coaxing and encouraging me but also understood when I was not feeling well one day, she was less insistent. The entire office works well together, not a "bad apple" in the bunch.

Jeanette, - Total Knee Replacement

Thanks to my care at UOS, I can resume normal activities after my Right,Total Knee Replacement.

I began seeing Dr. Holt and Erin a few years prior to my total knee replacement. Dr Holt accurately informed me how I would feel after surgery. The care I received from them before and during surgery was outstanding, and the care I am receiving after surgery is fantastic.

I began Physical Therapy at Turkey Creek after my knee replacement surgery. John, Lea, and Lynn are excellent and care about your success. During each visit they encourage you to do more than the last visit. They take the time to work with you, and provide exercises you need to do at home between appointments. The excellent care I received from them helped make my knee surgery a success.

When I have my left knee replaced, I will use Dr Holt and Physical Therapy at Turkey Creek.

John, - Right Knee Replacement/Therapy at Turkey Creek

Thanks to my care at UOS, I can...walk, Dr. Holt has an hand of God. I was told before I went to Dr. Holt that after my surgery I would be In a wheel chair for years. No I am not. I was happy to have him as my doctor and Kelly is good too. Thank GOD

Donna, - Total Knee Replacement

Thanks to my care at UOS, I can...walk without pain.

I have had both knees replaced, both shoulders reconstructed. This operation by Dr. Holt was, by far, the best results I have had with any surgery.

Thank You

Don, - Total Knee Replacement

Thanks to my care at UOS, I can walk in comfort.

Excellent doctor! Mike Holt did both of my knee replacements. Nurses were so kind with lots of TLC at UT Medical. Can't say enough about Dr. Holt. Have recommended him to many of my friends.

Beryl, - Knee Replacement

Thanks to my care at UOS, I can get back to a normal life and enjoy my new retirement and traveling Every staff member at the Turkey Creek clinic is kind and helpful. My husband and I have been to 2 different therapy clinics without much satisfaction. There's nothing like UOS Turkey Creek, where I received personal care, advice, and concern. My first day I sat on the table and cried, I was so afraid. John talked me through my fears and was there every visit with encouragement. Lynne & John expected me to work hard and I did better than I thought I could. I would highly recomend UOS Turkey Creek to any one, they are a talented and kind bunch of people. As soon as you walk through the door their receptionist will make you feel welcome. As much as it was hard work, I am going to miss seeing them 3 days a week!

Nadine, - Total Knee Replacement

Thanks to my care at UOS, I can walk with confidence. I also know where to go if the other knee gives out on me...

The results of the surgery simply amazed me. I was particularly impressed by the coordinated recovery between the doctors office and the extraordinary PT group in the same building in Turkey Creek. The therapy exceeded my expectations in every way. I left each session a little tired, a bit smarter, and a lot more confident. The training and advice is solid. Follow it and you will be on a trajectory to succeed beyond your expectations.

A word about pain management. I honestly found that the range of motion homework was very therapeutic. SERIOUSLY. If I woke up with pain, or found myself rather uncomfortable during the day, a few minutes of the stretches and bends (which are uncomfortable) brought almost instant relief after a few repetitions. The discomfort was reduced by more than half within a minute. There was not a pill in my house that could work that well or that fast.

If you hear this from your Therapist, BELIEVE.

Nathan, - Left Total Knee Replacement

Thanks to my care at UOS, I can walk without pain.

I had surgery on 4/18 and started PT on 4/21 at the Turkey Creek Clinic. I have been to 4 PT clinics before and this is the best by far. The therapists are very kind, compassionate, professional and genuinely care about their patients recovery. I would recommend this clinic to everyone.

May God bless each and everyone!!

Carol, - Total Knee Replacement
Frances Fern

Thanks to my care at UOS, I can walk with NO pain. I am very pleased with Dr. Holt and I highly recommend him. Not only is he an excellent surgeon but he has a very pleasing and most pleasant personality when he comes in the room.

Frances Fern, - Right Total Knee Replacement

Thanks to my care at UOS, I can... do the work and other things I could not do before. I am a pastor at a church and this was a great help to the lords work. Thanks again!

I traveled hundreds of miles to see Dr. Holt, and I will do it again if needed.

Jesse, - Right Knee Total Replacement

Thanks to my care at UOS, I can get back to doing normal things like walking, riding a bicycle with my granddaughter, doing volunteer work, all the things I couldn't do since my accident at work.

Dr. Holt is a highly skilled surgeon and a very compassionate man. He understood from the first visit how important it was for me to get the full use of my knee back. He didn't waste any time scheduling the necessary testing needed before my surgery and the surgery date. I will be forever grateful for all his God given qualities. Marissa Laws was my therapist there at UT. She helped me get to the point of recovery a lot faster than anticipated and I was released at 8 weeks instead of 12. I wish to thank them both for their loyalty to their professions.

Mindy, - Total Knee Replacement

Thanks to my care at UOS, I can...now go anywhere I want and do everything myself. I'm able to watch my great grandkids and go to parks and ball games with them. I just wish I had the procedure sooner. The care I received from Dr. Holt, and his assistant Erin, are very special to me. I was recommended to Dr. Holt and anybody who asks me, I tell them he is the best in this field. I am so glad he was my doctor.

Mary, - 2 Total Knee Replacements

Thanks to my care at UOS, I have returned to doing things I could not do in recent years. I cannot say enough about the care I received from the surgery, to the short care I received at UT hospital, to the awesome therapy I received at Turkey Creek. I had one knee replaced on September 8, 2016 and the other on November 1, 2016. The surgeries were successful and the therapists at Turkey Creek became like a second family. Recovery from knee replacement is not easy, but the therapists helped to make it a truly awesome experience. I am grateful each day for Dr. Holt and his staff and for the therapists at Turkey Creek. I would recommend them to anyone who needs knee replacement and therapy that follows.

Tom, - Total Knee Replacement

Thanks to my care at UOS, I can never explain how good it was to know that people really cared about i was going through.

Dr. Holt is a wonderful person that God has put here to help people and he does a great job. I have had both knees replaced now - I can walk without pain and I can play with my grandkids. Dr. Holt always explained everything to me so that i could understand and answered all my questions. He has a great bed side manner. THANKS Dr. Holt.

Tammy, - Total Knee Replacements

Thanks to my care at UOSortho, I can walk without pain. After 3 months I was released to continue my life with my new knee. Dr. Holt and all the folks working with him, helped me get back on my feet and I am doing well. My care was excellent by UOSortho. I would highly recommend Dr. Holt any time for a knee replacement.

Barb, Knee Replacement

Thanks to my care at UOS, I can... bend my knee back, walk as good as before my surgery. It takes about a good yr to get over the surgery, or it did me because I have a blood condition, and I was 73 when I had the surgery done. I am sure if you are younger you bounce back a lot better.

I would recommend Dr Holt, he a very good doctor, hope to never ned another replacement but if I did , I would want dr Holt to do the surgery.

William, Total knee replacement

Thanks to my care at UOS, I can now walk without pain-thanks to Dr. Holt. He, along with his assistant Erin took great pains to explain everything to me before the surgery. Then the procedure went very smooth and in 5 weeks I was able to graduate physical therapy. Life was about back to normal!! Thanks much

Gaylan, Total knee replacement

Thanks to my care at UOS, I can...now go back to having a normal life. For over a year prior to the surgery, I could barely walk and wore a steel knee brace all the time to walk as well as I did. It has been 3 months since my surgery and I am already back to my normal activities. I can't say enough good things about Dr. Holt. He has been not only a great surgeon, but he is kind and caring---not arrogant like so many ortho surgeons are.

I went to therapy for six weeks and have done all the exercises that I was told to do. It does exactly what the doctor and the therapist said it would. It gave me my life back.

Denise, Total Knee Replacement

Thanks to my care at UOS, I can...Walk without pain

Dr Holt and his staff were outstanding . The treatment I received was so professional and caring.. I truly they are miracle workers. I can function without pain for the first time in years.

I would highly them to anyone who wants the best there is.

Marilyn, Total Knee

"When I hobbled into Dr. Holt's office in October of 2013, I was not hopeful for a fix for my knees after being told by another physician two years prior I was not a candidate for knee replacement surgery. Five short weeks after double knee replacement surgery, my son and I hiked five miles at ElkMont and I have never looked back. Under the care of Dr. Holt, I am able to enjoy life again and making memories with my family hiking, biking, dancing and much more!"

Tom, Knee Replacement, Maryville, TN

"Dr. Holt has been providing care for our family for years. After years of hiking, tennis and a career in nursing, I became a patient and underwent OXINIUM bilateral knee replacement. His sincere and courteous bedside manner combined with his professionalism and expertise are unmatched and as a patient I truly believe I recovered faster and stronger under his direct care."

Malinda, Knee Replacement

"First I would like to thank God and next thank Dr. Holt and his team for giving me back my life. I had for many years been going to another doctor which wanted me to lost a lot of weight before he would do my surgery. I tried to lose but could not because when you can not walk, it is very hard to lose weight. I am sure the other doctor is a good doctor but this was just his policy.

I am so glad my son found you Dr. Holt, and your team, because I was on my way to a wheelchair. And now people see me and can not believe the difference this surgery had made. I can not believe it myself. I can go to any store or estate sales now. I have also lost 40 lbs since my first knee surgery in April.


I will continue to try to lose more weight because now I love to walk. I will forever hold Dr. Holt and his team close to my heart. God bless each of you."

Connie, Knee Surgery

Thanks to my great care at UOS, I can...now get around like i haven't in YEARS


Thanks to my care at UOS, I can...walk without pain.

I am particularly grateful to Dr. Holt for doing this surgery as another doctor had refused to do the surgery because I was past 80 years old. He did a great job and I had no complications. Thank you, Dr. Holt!

Georgia, Knee Replacement

Thanks to my care at UOS, I can... Work pain free while standing on my feet all day. I can walk pain free and climb stairs. Walking does not hurt my back and hips because of how I was walking before the procedure.

I had my first knee done in December and had no problems. Walking on my own within a week and a half without a walker or cane. No real pain that bothered me. Great, quick recovery back to work in 6 weeks at a standing job. Had second knee done at end of May. Pain was a little more than first procedure but tolerable with pain meds. Did not reach full range of motion quite as quick but doctor gave me a steroid injection and it made a real difference was back to work in 6 weeks. Over all I feel both procedures went well. I did a lot better with the first procedure than I had expected and recovery was faster than expected. I have been recommending Dr. Holt to all my friends and a lot of people have asked what Doctor did my surgery because of the speedy recovery with no complications.

Margie, Knee Replacement x2
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  • B.A., University of Tennessee, Knoxville, Tennessee, 1979
  • M.D., University of Tennessee Center for Health Services, Memphis, Tennessee 1983


  • General Surgery, Methodist Hospital – Central Memphis, Tennessee 1985
  • Orthopaedic Surgery, Campbell Foundation, Memphis, Tennessee 1989

Began Practice At UOS

  • 1989

Board Certification

  • American Board of Orthopaedic Surgery, 1991

Professional Distinctions

  • Memphis and Shelby County Medical Society
  • Tennessee Medical Association
  • American Medical Association
  • Knoxville Academy of Medicine, Inc.
  • University Medical Associates, Inc.
  • Willis C.Campbell Club
  • Knoxville Orthoapedic Society
  • Tennessee Orthopaedic Society
  • Fellow, American Academy of Orthopaedic Surgeons